Fresh vs. Frozen Embryo Transfer

13 Mar 2025

At Bangkok Central Clinic, the fertility clinic in Bangkok, we are aware that starting the road of in vitro fertilization (IVF) requires making important choices among which fresh and frozen embryo transfers is one of them. Both approaches have particular benefits and drawbacks. Our aim is to provide you with thorough knowledge that will allow you to make an informed choice that is suitable for your particular situation.

What is an Embryo Transfer?

Embryo transfer is a critically important step in the IVF process. After eggs are collected and fertilized in our laboratory, the resultant embryos may either be placed into the uterus immediately afterward (fresh transfer) or saved for future use (frozen transfer). 

What Is a Fresh Embryo Transfer?

In a fresh embryo transfer, embryos are transferred into the uterus normally within five days post-fertilization. With only a five-day waiting period between egg retrieval and embryo transfer, this method facilitates a shorter time to conception.

What Is a Frozen Embryo Transfer (FET)?

Frozen embryo transfer involves cryopreserving embryos for use in a subsequent cycle. This method offers flexibility, allowing for the synchronization of the embryo transfer with the optimal timing of the uterine environment. Additionally, FETs can be scheduled at a time that is most convenient for the patient.

Frozen transfers allow patients to recover fully from the stimulation phase of IVF, which can be physically and emotionally taxing. Additionally, they provide the opportunity for preimplantation genetic testing (PGT) to ensure the healthiest embryos are selected for transfer, further improving outcomes.

The Science Behind Freezing Embryos

Embryo freezing, also known as cryopreservation, involves rapidly cooling embryos using vitrification. This process prevents ice crystal formation, which can damage cells. Advances in cryopreservation techniques have significantly improved embryo survival rates after thawing, warming the frozen embryos, making frozen embryo transfers a reliable option for many patients.

Comparing Success Rates

Recent studies have indicated that frozen embryo transfers may offer higher pregnancy success rates compared to fresh transfers. This is attributed to the ability to optimize the uterine environment and the potential for better embryo selection. 

Potential Challenges of Each Approach

Fresh transfers are quicker but may have lower implantation rates due to a less synchronized uterine environment (the uterus may not be optimally prepared to receive the embryo). Frozen transfers require more time and money for cryopreservation (freezing and storing biological material) and storage, which may not suit all patients.

Who Might Benefit Most from Each Option?

Patients with certain medical conditions, such as endometriosis or elevated hormone levels during ovarian stimulation, may benefit more from frozen transfers to allow their bodies to recover. Conversely, younger patients or those with no underlying conditions might find success with fresh transfers, as timing is less of an issue.

Factors to Consider

When deciding between fresh and frozen embryo transfers, several factors should be taken into account:

Personal Health: If you have any health concerns, such as being at risk of ovarian hyperstimulation syndrome (OHSS), opting for a frozen embryo transfer could be a safer choice. 

Convenience: Frozen transfers offer the flexibility to schedule the procedure at a time that suits you best.

Embryo Viability: Not every embryo can withstand the freezing and thawing process, which could lead to a reduced number of embryos available for transfer.

Cost Considerations: It’s important to note that frozen embryo transfers often involve added costs, such as storage fees and thawing procedures. While these expenses can be an investment in achieving higher success rates, they may not be suitable for every budget.

Our Approach at Bangkok Central Clinic

At our fertility clinic in Bangkok, we provide both fresh and frozen embryo transfer options as part of our complete IVF procedures. Our team of professionals will work closely with you to find the most suited method based on your specific health profile and reproductive objectives. We are devoted to offering individualized treatment, combining the newest technology with empathetic assistance to enhance your chances of conceiving.  

Choosing between fresh and frozen embryo transfers is a key step in your reproductive journey. By learning the differences, advantages, and concerns of each approach, you can make an educated decision that coincides with your unique circumstances. Our healthcare team is here to accompany you every step of the process, delivering professional advice and specialized treatment to help you accomplish your goal of becoming a parent.